THE CHEMICAL TRANSMISSION OF VAGAL EFFECTS TO THE SMALL INTESTINE

Abstract

By the use of an intestinal loop in an intact animal as an indicator the production of an acetylcholine-like substance was shown to arise in the splanchnic area during vagal stimulation. That this substance came in part at least from the small intestine was demonstrated by perfusion of this organ and tests on the perfusate. To the perfusate both the frog''s heart and the eserinized leech responded in a manner typical for acetylcholine. The material could be demonstrated only when protected by eserine, its action was almost entirely abolished by atropine and it disappeared on standing. It is therefore believed to be acetylcholine-like and most likely acetylcholine itself. The demonstration of this chemical transmitter of parasympathetic impulses in an organ like the intestine which is somewhat atropine resistant is significant.