THE PROTECTIVE EFFECT OF ACUTE PHASE REACTANTS IN NEONATAL SEPSIS
- 1 September 1979
- journal article
- research article
- Published by Wiley in Acta Paediatrica
- Vol. 68 (5), 481-483
- https://doi.org/10.1111/j.1651-2227.1979.tb05044.x
Abstract
Phase reactants were evaluated prospectively in babies suspected of having sepsis. Among 318 babies, there were 22 proven and 10 “very probable” cases of neonatal sepsis. Of the proven cases 14 survived and 8 died. The survivors had a positive latex C-reactive protein (CRP) in 11 cases and an alpha1-acid glycoprotein (AGP) level greater than 0.5 g/l in 12 cases. Among those who died, one had a positive latex CRP and none had AGP >0.5 g/l. These findings were supported by positive CRP and elevated AGP in almost all “very probable” cases, all of whom survived. These data in newborn infants support the hypothesis that acute phase reactants have a functional role in combating infection.Keywords
This publication has 5 references indexed in Scilit:
- INTERACTIONS OF ALPHA1-ACID GLYCOPROTEIN WITH IMMUNE SYSTEM .1. PURIFICATION AND EFFECTS UPON LYMPHOCYTE RESPONSIVENESS1977
- Effects of C-Reactive Protein on the Lymphoid SystemThe Journal of Immunology, 1976
- The erythrocyte sedimentation rate in the newborn periodThe Journal of Pediatrics, 1975
- THE CLINICAL USEFULNESS OF C‐REACTIVE PROTEIN (CRP) DETERMINATIONS IN BACTERIAL MENINGITIS AND SEPTICEMIA IN INFANCYActa Paediatrica, 1974
- DIAGNOSTIC SIGNIFICANCE OF SERUM OROSOMUCOID LEVEL IN BACTERIAL INFECTIONS DURING NEONATAL PERIODActa Paediatrica, 1973