Renin Inhibition of Compensatory Renal Hypertrophy.

Abstract

Compensatory renal hypertrophy, already present 24 hours after uninephrectomy of female albino rats, is inhibited by injections of renin (5-60 dog units); the degree of inhibition is greater in animals treated for a 48 hour period. Renin is more active intraperitoneally than subcutaneously. This inhibition is not related to the catabolic effect of renin. It is absent in hypophysectomized animals. These experiments suggest that renin, like other hormones, can act as a self-regulating mechanism in the control of organ growth.