The Prognostic Significance of p53 Expression Quantitated by Computerized Image Analysis in Epithelial Ovarian Cancer

Abstract

The prognostic significance of p53 expression in 316 archival epithelial ovarian cancers was assessed using a static, computer-aided image analysis system (CAS 200). Using a 10% cut-off point, 26% of primary tumors and 35% of their metastases were positive for p53 protein. p53 positivity closely correlated with tumor grade (p 2 cm were significant predictors of poor overall survival. In both the overall (p