Thrombin Activatable Fibrinolysis Inhibitor (TAFI) at the Interface between Coagulation and Fibrinolysis
- 1 December 2003
- journal article
- review article
- Published by S. Karger AG in Pathophysiology of Haemostasis and Thrombosis
- Vol. 33 (5-6), 375-381
- https://doi.org/10.1159/000083832
Abstract
The thrombin-catalysed conversion of plasma fibrinogen into fibrin and the development of an insoluble fibrin clot are the final steps of the coagulation cascade during haemostasis. A delicate balance between coagulation and fibrinolysis determines the stability of the fibrin clot. Thrombin Activatable Fibrinolysis Inhibitor (TAFI) plays an important role in this process. TAFI is activated by thrombin and protects the fibrin clot against lysis. The role of TAFI in bleeding and thrombotic disorders is discussed as well as its novel emerging role in wound healing and inflammation.Keywords
This publication has 50 references indexed in Scilit:
- Inflammation in atherosclerosisNature, 2002
- Association of a single nucleotide polymorphism in CPB2 encoding the thrombin‐activable fibrinolysis inhibitor (TAFI) with blood pressureClinical Genetics, 2001
- Questions from QuebecBlood, 2001
- Plasma and Recombinant Thrombin-activable Fibrinolysis Inhibitor (TAFI) and Activated TAFI Compared with Respect to Glycosylation, Thrombin/Thrombomodulin-dependent Activation, Thermal Stability, and Enzymatic PropertiesPublished by Elsevier ,1998
- The Polymerization Pocket “a” within the Carboxyl-terminal Region of the γ Chain of Human Fibrinogen Is Adjacent to but Independent from the Calcium-binding SiteJournal of Biological Chemistry, 1997
- TAFI, or Plasma Procarboxypeptidase B, Couples the Coagulation and Fibrinolytic Cascades through the Thrombin-Thrombomodulin ComplexPublished by Elsevier ,1996
- Dental surgery in patients with severe factor XI deficiency without plasma replacementBlood Coagulation & Fibrinolysis, 1992
- Characterization of the binding of plasminogen to fibrin surfaces: The role of carboxy-terminal lysinesBiochemistry, 1991
- An arginine specific carboxypeptidase generated in blood during coagulation or inflammation which is unrelated to carboxypeptidase N or its subunitsBiochemical and Biophysical Research Communications, 1989
- C‐terminal lysine residues of fibrinogen fragments essential for binding to plasminogenFEBS Letters, 1985