The time of apperance of isoantibodies during the homograft response to mouse tumours.

Abstract

Whilst the ability of isoantibodies to agglutinate mouse red cells in saline medium does depend in part upon the properties of the antibody molecules, the concentration of antigen upon the red cell and certain genetically determined properties of the cell surface are of even greater importance. The red cells of mice of any strain will give positive results in the human serum:dextran system whilst reactions in a saline medium are unusual. In this paper the term `incomplete antibody' is used to denote antibodies that can only be detected in conjunction with other antibodies in the human serum:dextran system.