Structural identifiability of “first-pass” models
- 1 April 1987
- journal article
- conference paper
- Published by Springer Nature in Journal of Pharmacokinetics and Biopharmaceutics
- Vol. 15 (2), 179-189
- https://doi.org/10.1007/bf01062342
Abstract
This paper considers the structural identifiability of two compartmental models classically used to describe the pharmacokinetics of drugs orally administered and transformed into a metabolite with a firstpass effect at the hepatic level. The simplest model proves not to be globally identifiable even when plasma and urinary measurements of the drug and metabolite concentrations are made. It admits two sets of admissible solutions, so that a prioriknowledge must be introduced to distinguish them. The more complex model appears globally identifiable when blood and urine measurements are made.This publication has 9 references indexed in Scilit:
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