EARLY EXPERIMENTAL MYOCARDIAL-INFARCTION - EVALUATION OF HISTOLOGIC CRITERIA AND COMPARISON WITH BIOCHEMICAL AND ELECTROCARDIOGRAPHIC MEASUREMENTS
- 1 January 1976
- journal article
- research article
- Vol. 100 (10), 516-521
Abstract
Light microscopic criteria of early experimental myocardial infarction were compared with biochemical changes in glycogen content and the tissue K+/Na+ ratio in 19 mongrel dogs. Five sham-operated dogs served as controls, and 7 of the 14 dogs with experimentally induced infarcts received infusions of glucose, insulin and K (GIK). Infarcts were diagnosed by a scoring system based on edema formation, congestion, waviness of myofibers, myofibrillar degeneration, polymorphonucleosis, glycogen depletion and fuchsinorrhagia. Significant histologic scores were associated with tissue K+/Na+ ratios of less than 1.2, wiht 30% depletion of biochemical glycogen, and with epicardial ST-segment elevation. Progression of the infarction zone to involve the surrounding border zone was prevented by GIK infusions. Routine light microscopy used in conjunction with tissue K+/Na+ ratios enabled early infarction to be diagnosed with a high degree of accuracy.This publication has 6 references indexed in Scilit:
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