METABOLISM OF PARA-METHOXYAMPHETAMINE IN DOG AND MONKEY - O-DEMETHYLATION AS A MAJOR ROUTE

Abstract

P-Hydroxyamphetamine (PHA) (a psychoactive drug) and p-hydroxybenzoic acid (PHBA) were isolated by GLC as urinary metabolites of p-methoxyamphetamine (PMA) in dogs and rhesus monkeys. Amounts of PMA excreted unchanged in the total 24-h urine samples in dogs and monkeys were 26% and 3%, respectively, of the total administered doses. Amounts of the pharmacologically active metabolite PHA excreted in 24-h urine samples were 13% in the dog and 44% in the monkey. In the dog, 72% of the PHA was present as free (unconjugated) PHA, whereas in the monkey the PHA amount present in the free form was only 14%.