Electrophoretically pure mouse interferon exerts multiple biologic effects.
Open Access
- 1 October 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (10), 5308-5312
- https://doi.org/10.1073/pnas.76.10.5308
Abstract
Electrophoretically pure mouse interferon was examined for a number of biologic effects previously ascribed to crude or partially purified interferon preparations. These effects include: inhibition of the growth of a transplantable tumor in mice; inhibition of cell multiplication of mouse tumor cells in vitro; enhancement of the expression of histocompatibility antigens on mouse tumor cells in vitro; inhibition of antibody formation in vitro; inhibition of sensitization to sheep erythrocytes and the expression of delayed type hypersensitivity in mice; enhancement of natural killer cell activity in vivo and in vitro; enhancement of cell sensitivity to the toxicity of poly(I) .cntdot. poly(C); and enhanced production ("priming") of interferon production in vitro. The results establish that the molecules responsible for the antiviral action of interferon are also responsible for these varied biologic effects.This publication has 56 references indexed in Scilit:
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