A Fetal Hemoglobin Variant of Unusual Genetic Interest

Abstract

A fetal hemoglobin variant abnormal in the α peptide chains has been found in an umbilical cord blood sample obtained from an infant who had inherited Hb-G (presumably identical with G_Phila.) from his father. This provides evidence that α chain synthesis in fetal and adult life is under a single genetic control and that α chain mutations, unlike β chain mutations, may be manifested in intrauterine life.