THE RELATION BETWEEN PROTEIN CONSUMPTION AND DIURNAL VARIATIONS OF THE ENDOGENOUS CREATININE CLEARANCE IN NORMAL INDIVIDUALS 1

Abstract

The endogenous creatinine clearance is a valuable, simple, clinical test of renal function. It is affected slightly by the dietary protein consumption and by diurnal variations. These influences may be eliminated, for practical purposes, by collecting urine for the test during the morning after a creatinine-free breakfast. The normal endogenous creatinine clearance under such conditions is 176 1./24 hrs./70 kg. body wt., or 122 ml./min./70 kg. body wt. The normal mean serum creatinine concn. is 0.79 mg. % in women, slightly lower than in men. The normal mean endogenous creatinine clearance for women was detd. under one set of conditions and did not vary significantly from the values obtained in men.