A Low Serum Concentration of Mannan‐Binding Protein is Not Associated with Serogroup B or C Meningococcal Disease
- 1 April 1993
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 37 (4), 468-470
- https://doi.org/10.1111/j.1365-3083.1993.tb03320.x
Abstract
The mammalian C-type serum lectin, mannan-binding protein (MBP), may induce C1q- and antibody-independent activation of the classical pathway of complement. Accordingly, MBP is considered as a member of the complement system. Complement deficiencies have been found with increased frequency in patients with meningococcal disease. Therefore, we investigated the MBP levels in patients with meningococcal disease. Ninety-nine Norwegian individuals (age 12-21 years) who survived severe systemic disease caused by serogroup B or C meningococci were investigated. No significant differences were observed in the MBP concentration between patients with serogroup B (n = 76) or C (n = 25) disease and healthy blood donor controls (n = 40) (P > 0.05). The frequency of patients with low levels of MBP (< 100 micrograms/l) was 10.1%. This was not different from controls (12.5%). Thus, low MBP concentrations do not appear to predispose to serogroup B or C meningococcal disease.Keywords
This publication has 14 references indexed in Scilit:
- Low Prevalence of Complement Deficiencies among Patients with Meningococcal Disease in NorwayScandinavian Journal of Immunology, 1993
- DIALLELIC POLYMORPHISM MAY EXPLAIN VARIATIONS OF THE BLOOD CONCENTRATION OF MANNAN‐BINDING PROTEIN IN ESKIMOS, BUT NOT IN BLACK AFRICANSInternational Journal of Immunogenetics, 1992
- Gene frequency and partial protein characterization of an allelic variant of mannan binding protein associated with low serum concentrationsClinical and Experimental Immunology, 1992
- Bacterial Meningitis: Pathogenesis, Pathophysiology, and ProgressNew England Journal of Medicine, 1992
- C4B Deficiency Is Not Associated with Meningitis or Bacteremia with Encapsulated BacteriaThe Journal of Infectious Diseases, 1992
- DEFICIENCY OF MANNAN BINDING PROTEIN-A NEW COMPLEMENT DEFICIENCY SYNDROMEClinical and Experimental Immunology, 1991
- C4B Deficiency: A Risk Factor for Bacteremia with Encapsulated OrganismsThe Journal of Infectious Diseases, 1990
- COMPLEMENT DEFICIENCIES IN PATIENTS OVER TEN YEARS OLD WITH MENINGOCOCCAL DISEASE DUE TO UNCOMMON SEROGROUPSThe Lancet, 1989
- Association of Homozygous C4B Deficiency with Bacterial MeningitisThe Journal of Infectious Diseases, 1989
- Structures and functions associated with the group of mammalian lectins containing collagen‐like sequencesFEBS Letters, 1989