Chromosome Translocation t(14;22) and Oncogene (c-sis) Variant in a Pedigree with Familial Meningioma

Abstract

MANY cases of familial cancer have been reported, but relatively few inherited cancers have been shown to be associated with specific known genes or specific chromosome regions. Meningioma is an uncommon, usually sporadic, central nervous system tumor. In von Recklinghausen neurofibromatosis, brain tumors, including meningiomas, may occur in several members of a family.^{1 , 2} Familial meningioma not associated with another genetic syndrome has also been reported occasionally.^{3 4 5 6 7 8 9} The tumor tissue of sporadic meningiomas is often characterized by the absence of one of the No. 22 chromosomes or, less frequently, the absence of the distal part of the long arm of one . . .