Occlusive Vasculopathy in Systemic Lupus Erythematosus
- 1 February 1991
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Internal Medicine
- Vol. 151 (2), 389-392
- https://doi.org/10.1001/archinte.1991.00400020129028
Abstract
Patients with systemic lupus erythematosus and with antiphospholipid antibody are subject to sudden occlusion of multiple blood vessels. We describe two patients with systemic lupus erythematosus with acute, catastrophic, widespread non—inflammatory visceral vascular occlusions associated with hightiter antiphospholipid antibody. The histopathologic features clearly distinguished these patients from classic systemic lupus erythematosus vasculitis. We further suggest that, based on a probable pathogenesis related to the presence of antiphospholipid antibody, and based on the non—inflammatory vascular occlusion, steroids and other immunosuppressive medications are of limited value. Plasmapheresis along with anticoagulant therapy should be considered. (Arch Intern Med. 1991;151:389-392)Keywords
This publication has 1 reference indexed in Scilit:
- Pregnancy does not cause systemic lupus erythematosus to worsenArthritis & Rheumatism, 1989