Identification of a new member of the protegrin family by cDNA cloning
- 13 June 1994
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 346 (2-3), 285-288
- https://doi.org/10.1016/0014-5793(94)00493-5
Abstract
The porcine leukocyte protegrins are a family of cysteine-rich antimicrobial peptides the primary structures of which combine features of defensins and tachyplesins. We cloned three protegrins from porcine bone marrow mRNA by PCR, including one (PG-4) that was previously unknown. The 691 bp protegrin cDNAs were > 98.8% identical, and each was surrounded by highly conserved 5' and (in some instances) 3' sequences present in structurally dissimilar antimicrobial and LPS-binding peptides of animal leukocytes.Keywords
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