Effects of Certain Autonomic Blocking Agents on Striated Muscle Function

Abstract

The dog neuromuscular prepn. (gastrocnemius-soleus-internal popliteal nerve) was used to test the action at the striated myoneural junction of tetraethylammonium chloride (TEAC), hexamethonium bromide (C-6); pentamethyl-diethyl-3-aza-pentane-l,5-diammonium dibromide (P-9295); 2-benzyl-2-imidazoline hydrochloride (priscoline); and dimethyltubo-curarine (curare). The effects of these drugs singly and in combinations upon the muscular contractions following direct and indirect electrical stimulation, and the interactions of the drugs with epinephrine, K and prostigmine indicate that the striated myoneural junction is not analogous in all respects to the autonomic ganglionic synapse. The findings further indicate that the drugs tested do not act in a manner similar to curare or the depolarizing drugs.