Tumor Development in Mice Bearing a Plastic Cylinder and Inoculated With Human Neoplastic Cells 2

Abstract

From 2 stable lymphoma cell lines, human neoplastic cells, inoculated near a plastic cylinder implanted subcutaneously in 97 adult BALB/c mice, led to tumor development in 47% of the animals; allogeneic AKR lymphoma cells gave 73% tumor incidence; thus both values were significantly different from the 23% in control mice bearing only the Lucite cylinder. Tumor latency averaged 11 months. Transplants were easily obtained in syngeneic BALB/c mice but not in AKR; the karyotypes were murine. Histologically all tumors were similar and could be classified as anaplastic sarcomas. Intracisternal A-type virus particles were observed in tumor cells. It is postulated that both human and AKR lymphoma cells contain an agent capable of potentiating the tumorigenic effect of a plastic implant.