Beta-Blockers Versus Diuretics in Hypertensive Men: Main Results from the HAPPHY Trial

Abstract

Men aged 40-64 years with mild to moderate hypertension [diastolic blood pressure (DBP) 10CM30 mmHg] were randomized to treatment with a diuretic (n =3272) or a p-blocker (n =3297), with additional drugs if necessary, to determine whether a pblocker based treatment differs from thiazide diuretic based treatment with regard to the prevention of coronary heart disease (CHD) events and death. Patients with previous CHD, stroke or other serious diseases, or with contraindications to diuretics or p-blockers were excluded. If normotension (DBP