Gentamicin-induced Nephropathy
- 1 September 1976
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Infectious Diseases
- Vol. 8 (3), 203-208
- https://doi.org/10.3109/inf.1976.8.issue-3.16
Abstract
162 consecutive gentamicin courses have been evaluated retrospectively with respect to nephrotoxicity of gentamicin (GM). Of these, 120 courses were administered in 106 patients for more than 2 days and under adequate control of plasma creatinine (PCr). In 62 of these 120 courses, PCr concentrations increased. In 17 courses (14%), GM therapy was found to be the only demonstrable etiology to the rise in PCr. The 17 courses with GM-induced reduction in kidney function were characterized by a prolonged duration of treatment, a high total dose of GM and a somewhat higher level of serum GM than the 58 courses of GM treatment in which PCr remained unchanged. No significant differences were found with regard to age, average daily dose of GM, average daily dose per kg and average daily dose in proportion to average diuresis. Additional administration of other nephrotoxic drugs did not increase the incidence of GM-induced nephropathy. When GM was the only demonstrable cause of nephropathy, the elevation in PCr concentrations were generally mild and transient, while the nephropathy when other factors were involved more often became severe and occasionally irreversible.This publication has 6 references indexed in Scilit:
- GENTAMICIN AND RENAL FAILUREThe Lancet, 1972
- Renal Insufficiency Associated with Gentamicin TherapyThe Journal of Infectious Diseases, 1971
- Possible Nephrotoxicity of GentamicinThe Journal of Infectious Diseases, 1971
- Nephrotoxicity of Aminoglycosides and GentamicinThe Journal of Infectious Diseases, 1969
- Histological and Functional Changes in the Ears of Cats after Subcutaneous Administration of GentamicinThe Journal of Infectious Diseases, 1969
- Nephrotoxicity of Anti-Infective DrugsClinical Pediatrics, 1968