Experimental Unilateral Renal Artery Constriction in the Dog
- 1 May 1972
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 30 (5), 567-574
- https://doi.org/10.1161/01.res.30.5.567
Abstract
Chronic hypertension caused by unilateral constriction of the renal artery in the presence of the opposite untouched kidney can be produced in the dog by progressive plication of the renal artery over a period of several hours. Twenty-three female dogs were studied. Mean arterial blood pressure was measured in the unanesthetized recumbent dog by direct puncture of the femoral artery. Reproducible control blood pressure readings were obtained only after daily training of the animals for at least 2 months. Mean arterial blood pressure for the whole group of animals was 98.25 ± 7.45 (SD) mm Hg prior to constriction. Three months after constriction, the mean arterial blood pressure of the group of dogs with a 50-63% reduction in renal blood flow was 132.4 ± 5.51 (SD) mm Hg (P < 0.001); for the group with a 78-86% reduction in renal blood flow it was 144.68 ± 10.68 (SD) mm Hg (P < 0.001). Six dogs from these two groups underwent ipsilateral nephrectomies 4-16 months after constriction, and their elevated arterial blood pressures returned to preconstriction normal values. It was concluded that this type of experimental hypertension in the dog is renal dependent in both the acute and the chronic stages.Keywords
This publication has 15 references indexed in Scilit:
- Salt-rich Diet and Experimental Renovascular Hypertension in the RabbitThe Tohoku Journal of Experimental Medicine, 1969
- Renal alterations in dogs during renal arterial constriction, hemorrhagic hypotension and osmotic diuresisJournal of Surgical Research, 1965
- Initiation and maintenance of renal hypertensionThe American Journal of Surgery, 1964
- Hypertension of renal origin: Historical and experimental backgroundThe American Journal of Surgery, 1964
- RELATION OF RENIN, ANGIOTENSIN II, AND EXPERIMENTAL RENAL HYPERTENSION TO ALDOSTERONE SECRETION*JCI Insight, 1961
- Experience With a New Electro-Magnetic Flow-Meter for use in Blood-Flow Determinations in SurgeryAnnals of Surgery, 1960
- STUDIES ON THE RENAL ARTERIAL BLOOD PRESSURE AND THE METABOLISM OF KIDNEY TISSUE IN EXPERIMENTAL HYPERTENSIONThe Journal of Experimental Medicine, 1940
- STUDIES ON THE ETIOLOGY OF RENAL HYPERTENSIONAnnals of Surgery, 1937
- STUDIES ON EXPERIMENTAL HYPERTENSIONThe Journal of Experimental Medicine, 1937
- STUDIES ON EXPERIMENTAL HYPERTENSIONThe Journal of Experimental Medicine, 1934