Absence of Infectious HIV-1 in the Urine of Seropositive Viremic Subjects
- 1 December 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 160 (6), 1056-1060
- https://doi.org/10.1093/infdis/160.6.1056
Abstract
Urine and peripheral blood samples from 48 human immunodeficiency virus type 1 (HIV-1) seropositive individuals (38 adults and 10 children) were evaluated for the presence of HIV-1 by cocultivation and for HIV-1 p24 antigen by ELISA. None of the urine samples contained replication-competent HIV-1; 41 (851%) of 48 simultaneously obtained peripheral blood mononuclear cell samples contained replication-competent HIV-1. None of 26 urine samples available for analysis contained HIV-1 p24 antigen as determined by ELISA; 12 (34%) of 35 simultaneously obtained peripheral blood samples had detectable serum HIV-1 p24 antigen. Two of the individuals studied had HIV nephropathy, three had pyuria, and five had microscopic hematuria. Culture sensitivity was maximal when mycostatin (and not amphotericin B) was used as an antifungal agent. Our findings indicate that urine from HIV-1-seropositive individuals is unlikely to contain infectious HIV-1. This would imply that the risk of transmission of HIV-1 by urine is low to nonexistent.Keywords
This publication has 6 references indexed in Scilit:
- Bidirectional Interactions Between Human Immunodeficiency Virus Type 1 and CytomegalovirusThe Journal of Infectious Diseases, 1988
- Isolation Patterns of the Human Immunodeficiency Virus from Cervical Secretions During the Menstrual Cycle of Women at Risk for the Acquired Immunodeficiency SyndromeAnnals of Internal Medicine, 1987
- Risk of Human Immunodeficiency Virus Infection from Blood Donors Who Later Developed the Acquired Immunodeficiency SyndromeAnnals of Internal Medicine, 1987
- Induction of HTLV-III/LAV from a Nonvirus-Producing T-Cell Line: Implications for LatencyScience, 1986
- Infection by the Retrovirus Associated with the Acquired Immunodeficiency SyndromeAnnals of Internal Medicine, 1985
- Isolation of Human T-Cell Leukemia Virus in Acquired Immune Deficiency Syndrome (AIDS)Science, 1983