COMPARISON OF THE APPARENT RATE OF CORTISOL TURNOVER DETERMINED BY ISOTOPE DILUTION AND CORTISOL SECRETION RATE

Abstract
SUMMARY: The apparent rate of cortisol turnover was determined in conscious and anaesthetized sheep by injection of tritium-labelled cortisol. Simultaneously, the rate of cortisol secretion was determined by collection of adrenal venous blood. The apparent rate of cortisol turnover was found to be two to three times the rate of cortisol secretion.