GM1 ganglioside protects nucleus basalis from excitotoxin damage: Reduced cortical cholinergic losses and animal mortality
- 31 July 1988
- journal article
- research article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 20 (4), 479-483
- https://doi.org/10.1002/jnr.490200411
Abstract
Ten days after bilateral injections of ibotenic acid into the nucleus basalis, rats injected daily (i.m.) with ganglioside GM1 were protected from anterograde degeneration of cholinergic projections to the frontolateral cortex. This protection was reflected by reduced losses (associated with ibotenic acid lesions) of cortical acetylcholinesterase, choline acetyltransferase, and lowered animal mortality.Keywords
This publication has 36 references indexed in Scilit:
- Ganglioside-induced alterations in hippocampal cholinergic enzymes and Na, K-ATPase after fimbria-fornix transectionJournal of Neuroscience Research, 1987
- Ganglioside treatment: Reduction of CNS injury and facilitation of functional recoveryBrain Injury, 1987
- Administration of GMI. ganglioside restores the dopamine content in striatum after chronic treatment with MPTPNeuropharmacology, 1986
- GM1 ganglioside facilitates the recovery of high‐affinity choline uptake in the cerebral cortex of rats with a lesion of the nucleus basalis magnocellularisJournal of Neuroscience Research, 1984
- Reduction of cerebral edema with GM1 gangliosideJournal of Neuroscience Research, 1983
- Ganglioside treatment improves recovery of alternation behavior after unilateral entorhinal cortex lesionExperimental Neurology, 1983
- SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASEThe Lancet, 1976
- Biosynthesis and Function of GangliosidesScience, 1976
- N‐ACETYLNEURAMINIC ACID MOLECULES AS POSSIBLE SEROTONIN BINDING SITES1Journal of Neurochemistry, 1976
- On the Evaluation of the Constants
V
m
and
K
M
in Enzyme ReactionsScience, 1952