Infectious background of patients with a history of acute anterior uveitis
Open Access
- 1 November 2002
- journal article
- other
- Published by BMJ in Annals Of The Rheumatic Diseases
- Vol. 61 (11), 1012-1016
- https://doi.org/10.1136/ard.61.11.1012
Abstract
Objective: To study the infectious backround of patients with a history of acute anterior uveitis (AAU) and healthy control subjects. Methods: Sixty four patients with previous AAU and 64 sex and age matched controls were studied. Serum antibodies to Salmonellae, Yersiniae, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Campylobacter jejuni, and Borrelia burgdorferi were measured using enzyme linked immunosorbent assay (ELISA), and antibodies to Chlamydia trachomatis and Chlamydia pneumoniae by microimmunofluorescence test. Peripheral blood mononuclear cells (PBMCs), separated by density gradient centrifugation, were studied for Salmonella and Yersinia antigens by means of an immunofluorescence test, and for C pneumoniae DNA with a polymerase chain reaction (PCR). Results: Neither prevalence nor levels of single microbial antibodies studied differed between the patients and control subjects, or between subgroups of patients created on the basis of clinical characteristics. In logistic regression analysis, the high number of recurrences (>10) of AAU was independently related to the presence of single or multiple bacterial antibodies (p=0.04). None of the PBMC samples of the patients were positive for Yersinia or Salmonella antigens. C pneumoniae PCR was positive in a patient who was negative for C pneumoniae antibodies. Conclusion: Although neither the prevalence nor the levels of single microbial antibodies studied differed between the patients and the controls, current data suggest that the presence of single or multiple antibodies in patients with many recurrences of AAU compared with patients with none or few recurrences may be a sign of repeated infections, antigen persistence, or raised innate immune responsiveness.This publication has 50 references indexed in Scilit:
- Systemic inflammation and innate immune response in patients with previous anterior uveitisBritish Journal of Ophthalmology, 2002
- Prevalence of Chlamydia trachomatis in urine of male patients with ankylosing spondylitis is not increasedAnnals Of The Rheumatic Diseases, 2000
- The influence of HLA B27 and interferon-γ on the invasion and persistence of yersinia in primary human fibroblastsMedical Microbiology and Immunology, 1996
- ANTIBODIES TO KLESBSIELLA PNEUMONIAE, ESCHERICHIA COLI AND PROTEUS MIRABILIS IN THE SERA OF ANKYLOSING SPONDYLITIS PATIENTS WITH /WITHOUT IRITIS AND ENTHESITISRheumatology, 1995
- Bacterial antigens in synovial biopsy specimens in yersinia triggered reactive arthritis.Annals Of The Rheumatic Diseases, 1991
- Susceptibility of HLA-B27 transgenic mice to Yersinia enterocolitica infectionHuman Immunology, 1990
- Yersinia Antigens in Synovial-Fluid Cells from Patients with Reactive ArthritisNew England Journal of Medicine, 1989
- MONOCLONAL ANTIBODIES REACTING SELECTIVELY WITH CORE AND O‐POLYSACCHARIDE OF YERSINIA ENTEROCOLITICA O:3 LIPOPOLYSACCHARIDEActa Pathologica Microbiologica Scandinavica Series C: Immunology, 1987
- Chlamydial immunofluorescence serology in anterior uveitis.British Journal of Ophthalmology, 1982
- Acute anterior uveitis after yersinia infection.British Journal of Ophthalmology, 1982