The Use of Testosterone in the Treatment of Depressions

Abstract

Sex hormones and related substances have been used in the treatment of depressions for a number of years. Although the use of estrogenic substances of various types has yielded disappointing results in deeply depressed women, the injection of testosterone has been known for a decade or more to cause remission in male patients with depressions, provided large doses are used. Danziger and Blank¹ reviewed the earlier clinical literature bearing on this point; a more recent review by Danziger et al.² is also available. The rationale for the use of testosterone in the past has been that of replacement therapy in . . .