HYDROXY‐INDOLE‐O‐METHYLTRANSFERASE ACTIVITY IN HUMAN PINEALS: A COMPARISON OF CONTROLS AND SCHIZOPHRENICS
- 1 September 1983
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 19 (3), 313-317
- https://doi.org/10.1111/j.1365-2265.1983.tb00004.x
Abstract
The activity of hydroxy-indole-o-methyltransferase (HIOMT) was assayed in pineal glands from 15-controls and 23 schizophrenics. There was no significant difference between the 2 groups in HIOMT activity and no significant effect of age, sex or neuroleptic treatment on the activity of the enzyme. A diurnal rhythm was not discernible in HIOMT activity and it is suggested that this may be the result of terminal illness. Apparently, HIOMT activity in pineals of schizophrenics is unlikely to differ from controls.This publication has 18 references indexed in Scilit:
- REDUCED NOCTURNAL MELATONIN SECRETION IN CHRONIC SCHIZOPHRENIA: RELATIONSHIP TO BODY WEIGHTClinical Endocrinology, 1982
- Concentration of 5-methoxyindoles in the human pineal glandJournal of Neural Transmission, 1982
- HUMAN POST‐MORTEM PINEAL ENZYME ACTIVITYClinical Endocrinology, 1981
- ABNORMAL 24 HOUR PATTERN OF MELATONIN SECRETION IN DEPRESSIONThe Lancet, 1979
- The effect of neuroleptic drugs on serum and cerebrospinal fluid melatonin concentrations in psychiatric subjectsJournal of Pharmacy and Pharmacology, 1979
- INCREASED DOPAMINE-RECEPTOR SENSITIVITY IN SCHIZOPHRENIAThe Lancet, 1978
- Melatonin Content of the Human Pineal GlandScience, 1978
- Elevated Melatonin Serum Concentrations in Psychiatric Patients Treated with ChlorpromazineJournal of Pharmacy and Pharmacology, 1977
- The pineal and psychiatry: a reviewPsychological Medicine, 1977
- Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N -AcetyltransferaseScience, 1970