Antiparasitic Drugs. II. Anticoccidial Activity of 4,5 imidazoledicarboxamide and Related Compounds

Abstract

The preparation of 7 substituted imidazoles is described and the relative anticoccidial potency of 17 imidazole compounds determined. Anticoccidial activity was demonstrated for imidazole-4-carboxamide and certain related compounds. The most potent compound was 4,5-imidazoledicarboxamide (glycarbylamide), which effectively controlled cecal coccidiosis in chicks at 0.002% concentration in the feed. Replacement of one or both carboxamides in the 4,5 positions on the imidazole ring reduced or completely eliminated the anticoccidial activity of glycarbylamide. Substitutions at the 1 or 2 positions on the imidazole ring produced compounds of less activity than glycarbylamide.