Two cases of sepsis and meningitis due to Group B beta-hemolytic streptococci occurred within 1 week in newborns on a small maternity unit in southwestern Alaska. The same physician and nurse cared for the first infant during his terminal illness, while simultaneously attending the labor and delivery of the mother of the second infant. Although the coincidental occurrence of these two infections could not be ruled out, cross infection may well have occurred during that critical interval.