Binding of horseradish peroxidase-?-bungarotoxin to axonal membranes at the node of ranvier
- 1 September 1980
- journal article
- research article
- Published by Wiley in Journal of Comparative Neurology
- Vol. 193 (1), 179-185
- https://doi.org/10.1002/cne.901930112
Abstract
The binding of horseradish peroxidase (HRP)‐labeled α‐bungarotoxin (α‐BuTx) was investigated in rat sciatic nerve. Activity was found to be localized to the axolemma of myelinated nerve fibers at the nodes of Ranvier. Activity was also seen in other regions of the axolemma where the myelin sheath was separated from the axon by enzymatic treatment. Pretreatment of nerves with native α‐BuTx or curare blocked the binding of HRP‐α‐BuTx to the axonal membranes. This study demonstrates binding of α‐BuTx to axonal membranes although the nature and significance of the toxin receptor is uncertain.This publication has 22 references indexed in Scilit:
- Localization of horseradish peroxidase-alpha-bungarotoxin binding in crustacean axonal membrane vesicles and intact axons.Proceedings of the National Academy of Sciences, 1979
- Synthesis, insertion into the plasma membrane, and turnover of alpha-bungarotoxin receptors in chick sympathetic neurons.The Journal of cell biology, 1979
- Intramembranous particles at the nodes of Ranvier of the cat spinal cord: A morphometric studyBrain Research, 1978
- Nonequivalence of alpha-bungarotoxin receptors and acetylcholine receptors in chick sympathetic neurons.Proceedings of the National Academy of Sciences, 1978
- Ultrastructural localization of the acetylcholine receptor in myasthenia gravis and in its experimental autoimmune modelNeurology, 1977
- α-Bungarotoxin used as a Probe for Acetylcholine Receptors of Cultured NeuronesNature, 1973
- Chemistry and Pharmacology of Polypeptide Toxins in Snake VenomsAnnual Review of Pharmacology, 1972
- The ultrastructure of the nodes of ranvier in cat sympathetic nerve fibersJournal of Ultrastructure Research, 1961
- The action of acetylcholine and some related substances on conduction in mammalian non‐myelinated nerve fibresThe Journal of Physiology, 1961
- Effect of Curare on Conduction in Myelinated, Isolated Nerve Fibres of the FrogNature, 1960