Lyophilization of Poliomyelitis Virus. Heat Inactivation of Dry MEF1 Virus.

Abstract

The MEF1 baby mouse adapted strain of type 2 poliomyelitis virus can be lyophilized with little loss of infectious activity. The same appears to be true of Leon (type 3) mouse adapted virus. Heating of dry MEF1 virus indicates that, although a part of the viral population appears to be relatively heat labile, a measurable proportion is quite heat resistant. The epidemiological implications of the dry virus in nature are discussed.