The growth hormone response to repeated bouts of sprint exercise with and without suppression of lipolysis in men
- 1 March 2008
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 104 (3), 724-728
- https://doi.org/10.1152/japplphysiol.00534.2007
Abstract
A single 30-s sprint is a potent physiological stimulus for growth hormone (GH) release. However, repeated bouts of sprinting attenuate the GH response, possibly due to negative feedback via elevated systemic free fatty acids (FFA). The aim of the study was to use nicotinic acid (NA) to suppress lipolysis to investigate whether serum FFA can modulate the GH response to exercise. Seven nonobese, healthy men performed two trials, consisting of two maximal 30-s cycle ergometer sprints separated by 4 h of recovery. In one trial (NA), participants ingested NA (1 g 60 min before, and 0.5 g 60 and 180 min after sprint 1); the other was a control (Con) trial. Serum FFA was not significantly different between trials before sprint 1 but was significantly lower in the NA trial immediately before sprint 2 [NA vs. Con: mean (SD); 0.08 (0.05) vs. 0.75 (0.34) mmol/l, P < 0.05]. Peak and integrated GH were significantly greater following sprint 2 compared with sprint 1 in the NA trial [peak GH: 23.3 (7.0) vs. 7.7 (11.9) μg/l, P < 0.05; integrated GH: 1,076 (350) vs. 316 (527) μg·l−1·60 min−1, P < 0.05] and compared with sprint 2 in the Con trial [peak GH: 23.3 (7.0) vs. 5.2 (2.3) μg/l, P < 0.05; integrated GH: 1,076 (350) vs. 206 (118) μg·l−1·60 min−1, P < 0.05]. In conclusion, suppressing lipolysis resulted in a significantly greater GH response to the second of two sprints, suggesting a potential role for serum FFA in negative feedback control of the GH response to repeated exercise.Keywords
This publication has 25 references indexed in Scilit:
- Post-exercise abdominal, subcutaneous adipose tissue lipolysis in fasting subjects is inhibited by infusion of the somatostatin analogue octreotideClinical Physiology and Functional Imaging, 2007
- The validity of capillary blood sampling in the determination of human growth hormone concentration during exercise in menBritish Journal of Sports Medicine, 2004
- Suppressing lipolysis increases interleukin-6 at rest and during prolonged moderate-intensity exercise in humansJournal of Applied Physiology, 2004
- Regulation of MDCK cell-substratum adhesion by RhoA and myosin light chain kinase after ATP depletionAmerican Journal of Physiology-Cell Physiology, 2004
- Hypothalamic Mediated Action of Free Fatty Acid on Growth Hormone Secretion in SheepEndocrinology, 1998
- Influence of metabolic substrates and obesity on growth hormone secretionTrends in Endocrinology & Metabolism, 1995
- Acute effects of high fat and high glucose meals on the growth hormone response to exercise.Journal of Clinical Endocrinology & Metabolism, 1993
- A power primer.Psychological Bulletin, 1992
- Regulation of epidermal-growth-factor-receptor signal transduction by cis-unsaturated fatty acids. Evidence for a protein kinase C-independent mechanismBiochemical Journal, 1991
- Free Fatty Acids Block Growth Hormone (GH) Releasing Hormone-Stimulated GH Secretion in Man Directly at the Pituitary*Journal of Clinical Endocrinology & Metabolism, 1987