Metabolism of [14C]arachidonic acid by polymorphonuclear leukocytes in patients with psoriasis
- 1 February 1987
- journal article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 116 (2), 153-159
- https://doi.org/10.1111/j.1365-2133.1987.tb05806.x
Abstract
The formation of LTB4 and its ω‐oxidation products 20‐hydroxy‐ and 20‐carboxy‐LTB4 from exogenous [14C] arachidonic acid (AA) by neutrophils from 12 psoriatic patients and 10 healthy controls was investigated. Only a slight difference was detected in the mean amount of [14C]LTB4 produced. In contrast, the amounts of [14C]ω‐oxidation products obtained from psoriatic PMN were 2.4‐fold higher than the amounts from PMN of healthy controls. We conclude that in vitro, psoriatic PMN synthesize more LTB4 from exogenous AA than do PMN of healthy individuals and due to an efficient ω‐oxidation system, the net release of LTB4 in both groups appears to be similar.Keywords
This publication has 16 references indexed in Scilit:
- Arachidonic acid metabolism by polymorphonuclear leukocytes in psoriasisBritish Journal of Dermatology, 1986
- Selective expression of 15-lipoxygenase activity by cultured human keratinocytesBiochemical and Biophysical Research Communications, 1985
- Effect of leukotrienes on endothelium and the transendothelial migration of neutrophilsJournal of Allergy and Clinical Immunology, 1984
- The Release of Leukotriene B4-like Material in Biologically Active Amounts from the Lesional Skin of patients with PsoriasisJournal of Investigative Dermatology, 1984
- Identification of Chemotactic Lipoxygenase Products of Arachidonate Metabolism in Psoriatic SkinJournal of Investigative Dermatology, 1984
- PSORIASIS AND LEUKOTRIENE B4The Lancet, 1982
- Stimulation of human leukocyte degranulation by leukotriene B4 and its ω‐oxidized metabolitesFEBS Letters, 1981
- Novel structural determinants of the human neutrophil chemotactic activity of leukotriene B.The Journal of Experimental Medicine, 1981
- Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytesNature, 1980
- The Primary Histologic Lesion of Seborrheic Dermatitis and Psoriasis*Journal of Investigative Dermatology, 1966