Modification of Silicon AFM Cantilever Tips with an Oligo(ethylene glycol) Derivative for Resisting Proteins and Maintaining a Small Tip Size for High-Resolution Imaging
- 28 May 2003
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (25), 7498-7499
- https://doi.org/10.1021/ja0350435
Abstract
We demonstrate that silicon AFM tips can be modified by etching with 2% HF solution followed by reaction with an α,ω-oligo(ethylene glycol)alkene. Tips properly modified by this technique maintain a small tip size and effectively reduce the nonspecific interaction with fibrinogen and bovine serum albumin, resulting in greatly improved image resolution and contrast for high-coverage fibrinogen films.Keywords
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