Triphlorethol‐A induces heme oxygenase‐1 via activation of ERK and NF‐E2 related factor 2 transcription factor
Open Access
- 20 April 2007
- journal article
- Published by Wiley in FEBS Letters
- Vol. 581 (10), 2000-2008
- https://doi.org/10.1016/j.febslet.2007.04.022
Abstract
Triphlorethol‐A, phlorotannin found in Ecklonia cava, induced heme oxygenase‐1 (HO‐1) expression at mRNA and protein levels, leading to increased HO‐1 activity. Transcription factor NF‐E2 related factor 2 (Nrf2) regulates antioxidant response element (ARE) of phase 2 detoxifying and antioxidant enzymes. Triphlorethol‐A increased nuclear translocation, ARE binding, and transcriptional activity of Nrf2. Triphlorethol‐A exhibited activation of ERK and U0126, inhibitor of ERK kinase, suppressed triphlorethol‐A induced activation of Nrf2, finally decreased HO‐1 protein level. Taken together, these data suggest that triphlorethol‐A augments cellular antioxidant defense capacity through induction of HO‐1 via ERK‐Nrf2‐ARE signaling pathway, thereby protecting cells from oxidative stress.Keywords
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