Utility of tris(dimethylamino)sulphonium difluorotrimethylsilicate (TASF) for the rapid synthesis of deoxyfluoro sugars

Abstract

The fluoride ion displacement of carbohydrate trifluoromethanesulphonates using tris(dimethylamino)sulphonium difluorotrimethylsilicate (TASF) provides a convenient route to deoxyfluoro sugars; the rapidity of the reaction makes it of interest for the potential synthesis of fluorinated-carbohydrate radiopharmaceuticals for use in medical imaging.