A dimethoxynaphthalene derivative (RS-43179 gel) compared with 0.025% fluocinolone acetonide gel in the treatment of psoriasis

Abstract

Patients [30] were entered into a double-blind trial comparing a dimethoxynaphthalene derivative (RS-43179 gel) and fluocinolone acetonide (Synalar gel) in the treatment of psoriasis. The 2 preparations were applied 3 times daily for 4 wk, and the patients were assessed at weeks 1, 2, 3, 4, 7 and 9. No significant differences between the 2 preparations could be detected. By the end of the 4-wk treatment period, the number of patients showing a good, excellent or clear therapeutic response was 25 of 28 after RS-43179 treatment and 26 of 28 after Synalar treatment. Four patients experienced irritation on the side treated with RS-43179. In 2 of these patients the reaction was severe and the treatment was discontinued, but in the other 2 patients, the local irritation was only moderate. No other adverse reactions were seen.