A simple route to α-aminoketones and related derivatives by dianion acylation reactions; an improved preparation of δ-aminolevulinic acid

Abstract

Acylation of the dianion (1) derived from ethyl hippurate (2) using anhydrides, followed by acid hydrolysis, provides a general route to α-aminoketones; a short and convenient preparation of the porphyrin precursor δ-aminolevulinic acid (as the hydrochloride) by the foregoing procedure is described.