Prevention of virus-induced neoplasms in mice through passive transfer of immunity by sensitized syngeneic lymphoid cells.
- 1 April 1967
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 57 (4), 1068-1075
- https://doi.org/10.1073/pnas.57.4.1068
Abstract
Polyoma virus-induced neoplasms in C57BL strain mice were totally prevented through adoptively acquired immunity. Sensitized lymphoid cells inoculated intravenously were effective if administered as late as 30 days after virus infection. Sensitized allogeneic lymphoid cells, killed syngeneic cells, and serum from hyperimmunized donors were ineffective. The antigenic difference between tumor and host can be used to control primary tumors. Clones of neoplastic cells induced by virus and containing TR [trans-plantation-resistance]/antigen are eliminated by an immune reaction of the homograft type.Keywords
This publication has 17 references indexed in Scilit:
- Effect of Thymectomy on Transplantation Resistance induced by Polyoma Tumour HomograftsNature, 1966
- STUDIES OF THYMIC FUNCTION WITH EMPHASIS ON ROLE OF THYMUS IN ONCOGENESIS1966
- TREATMENT OF PRIMARY FIBROSARCOMA IN THE RAT WITH IMMUNE LYMPHOCYTESThe Lancet, 1964
- Influence of Thymectomy on Tumor Induction by Polyoma Virus in C57BL MiceExperimental Biology and Medicine, 1964
- The oncogenic activity of the polyoma virus in thymectomized ratsLife Sciences, 1963
- IMMUNOLOGICAL DETERMINANTS OF POLYOMA VIRUS ONCOGENESISThe Journal of Experimental Medicine, 1962
- DEMONSTRATION OF RESISTANCE AGAINST METHYLCHOLANTHRENE-INDUCED SARCOMAS IN THE PRIMARY AUTOCHTHONOUS HOST1960
- Plaque production by the polyoma virusVirology, 1959
- STUDIES ON THE IMMUNOLOGICAL RESPONSE TO FOREIGN TUMOR TRANSPLANTS IN THE MOUSEThe Journal of Experimental Medicine, 1955