Serum proteins neutralize the toxic effect of lysophosphatidyl choline
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Current Eye Research
- Vol. 2 (9), 621-624
- https://doi.org/10.3109/02713688208996363
Abstract
Lysophosphatidyl choline (LPC), which was shown to be toxic to the lens in organ culture, is markedly elevated iun uveitic eyes. These findings have led to the suggestion that LPC is an initiator of catarctogenesis in uveitis. A factor not considered by previous investigators, i.e., the presence of serum proteins, can modulate LPC toxicity in vitro. The toxicity of LPC to lens epithelial cells or to whole lens in organ culture [from mice] was effectively neutralized by addition of serum or serum albumin to the test cultures, thus suggesting that the potential toxicity of the increased LPC in the uveitic eye might be neutralized by the concomitant increase in serum protein. The susceptibility to LPC toxicity of lens epithelial cells was not greater than that of lymphocytes which are normally exposed to LPC levels higher than those in the uveitic eye.This publication has 9 references indexed in Scilit:
- Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albuminCurrent Eye Research, 1981
- INHIBITION OF DNA AND RNA-SYNTHESIS IN LYMPHOCYTE-CULTURES BY ROD OUTER SEGMENTS AND ITS COUNTERACTION BY VITAMIN-E AND OTHER ANTIOXIDANTS1980
- Phospholipid effects on the rat lens transport systemsExperimental Eye Research, 1978
- Lipids in tissues of the eye. XVI. Uptake of lipids by the rabbit lens in vitroExperimental Eye Research, 1978
- SYNTHESIS OF GAMMA-CRYSTALLIN BY A CLONED CELL LINE FROM NAKANO MOUSE LENS1978
- TISSUE-CULTURE OF LENS EPITHELIAL-CELLS FROM NORMAL AND NAKANO MICE1977
- Lysophosphatidyl Choline and Cataracts in UveitisArchives of Ophthalmology (1950), 1976
- Aspirin Prevents the Disruption of the Blood–Aqueous Barrier in the Rabbit EyeNature, 1972