Breast Milk Jaundice: Effect of 3 20 -pregnanediol on Bilirubin Conjugation by Human Liver
Open Access
- 1 April 1970
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 45 (240), 186-189
- https://doi.org/10.1136/adc.45.240.186
Abstract
The effect of 3α,20β-pregnanediol and other steroids on bilirubin conjugation was examined using liver tissue from human and four other species. Neither 3α,20β-pregnanediol nor 3α,20β-pregnanediol inhibited conjugation by human liver slices or by solubilized human liver microsomes. 3α,20β-pregnanediol is unlikely to be the inhibitor causing breast milk jaundice. Oestriol inhibited conjugation by human liver slices. A comparison of species indicated that the response of the human liver slice system to steroids resembles that of the rabbit and guinea-pig rather than the rat or mouse.Keywords
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