The role of trace elements and phosphates in the synthesis of vascular-permeability factor by Vibrio cholerae

Abstract
Trace element and phosphate requirements for the synthesis of vascular-permeability factor (PF) by V. cholerae strains B1307 and VC12 were investigated. While Mg appeared to be indispensable for strain VC12, small amounts of PF were synthesized by strain B1307 in the presence of Fe, Zn and Mn. Even in the latter strain, maximum synthesis was recorded only in Mg containing media. Phosphates in the range 0.75-6.00 mM controlled the synthesis of PF by both strains.