POSSIBLE TUMOR LOCALIZATION OF TC-99M-LABELED LIPOSOMES - EFFECTS OF LIPID-COMPOSITION, CHARGE, AND LIPOSOME SIZE

Abstract

The possible in vivo distribution of liposomes after they are directly labeled with 99mTc was studied in rats bearing the Walker 256 carcinoma. The importance of lipid composition, charge and size of liposome were studied with respect to possible tumor-localizing properties. Tumor uptake was best with small, fluid-membrane, negatively charged liposomes, as indicated by the distribution of the 99mTc label. Uptake was visualized on scintigrams.