Naloxone Fails to Antagonize the Righting Response in Rats Anesthetized with Halothane

Abstract

The righting responses of 75 Wistar rats during exposure to halothane, 0.5%, 10 min after s.c. injection of naloxone, 10 or 20 mg/kg, or saline solution were examined. There was no difference in recoveries of the righting responses among the 3 groups. Naloxone does not antagonize the loss of righting response produced by halothane anesthesia in the rat.