SPECIFIC CYTOSOL RECEPTORS FOR 1,25-DIHYDROXYVITAMIN D3IN HUMAN INTESTINE
- 1 April 1979
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 48 (4), 715-717
- https://doi.org/10.1210/jcem-48-4-715
Abstract
Human intestine is shown to contain a specific, high affinity cytosol receptor or binding protein for 1,25-(OH)2 -vitamin D3 [1,25(OH)2 D3 ]. This receptor is a protein which sediments at 3.5S on sucrose gradients containing 0.3 M KC1. The receptor binds 1,25(OH)2 D3 with a Kd of approximately 2 × 10-10 M at 4°C. Competition binding studies using structural analogs of l,25(OH)2 D3 indicate that the relative specificity of the receptor is 1,25(OH)2 D3 > 1,24R,25(OH)3 D3 >> 25OHD3 1 OHD3 > 24R,25(OH)2 D3.Keywords
This publication has 1 reference indexed in Scilit:
- Specific cytosol-binding protein for 1,25-dihydroxyvitamin D3 in rat intestine.Journal of Biological Chemistry, 1977