Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm
Open Access
- 1 May 1991
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 35 (5), 1008-1010
- https://doi.org/10.1128/aac.35.5.1008
Abstract
Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth could be a major reason for the persistence of this sessile bacterium in chronic infections.Keywords
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