Comparison of Viral Marker Proteins in Murine Leukemia Virus and Mouse Uterus

Abstract

RNA-directed DNA polymerase and group-specific antigen were found in uteri of NIH Swiss mice in response to estrogen treatment. The viral markers from the uterus sedimented more rapidly on glycerol gradients than did the corresponding proteins from Rauscher leukemia virus, which indicated that the uterine proteins were of larger molecular weight. Template requirements of the polymerases from uterus and virus were similar, and both enzymes were inhibited by immunoglobulin G prepared against purified murine leukemia viral polymerase.