Increase of Human Plasma GABA by Sodium Valproate
- 1 December 1980
- Vol. 21 (6), 611-615
- https://doi.org/10.1111/j.1528-1157.1980.tb04314.x
Abstract
Gamma-Aminobutyric acid (GABA) was measured in the plasma of volunteers during subchronic treatment with sodium valproate (VPA). After 2 days of oral treatment with 300 mg VPA, t.i.d., the GABA concentration was increased to about 30% compared to 2 control days. This response was similar to that after 2 days of treatment with 600 mg VPA, t.i.d., whereas on the fourth day of treatment with the latter dose, a plasma GABA increase of about 90% was observed.Keywords
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