Polymorphisms in the 5′-Flanking Region of the Insulin Gene and Non-Insulin-Dependent Diabetes
- 1 April 1984
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 66 (4), 383-388
- https://doi.org/10.1042/cs0660383
Abstract
DNA insertions in the 5''-flanking region of the insulin gene were studied by Southern blot hybridization techniques using a cloned gene probe in 159 unrelated caucasians. Subjects homozygous for a large DNA insertion at this locus had a higher risk of concurrence of non-insulin-dependent diabetes (NIDD) than controls (P < 0.01). Analysis of a single large NIDD predigree (n = 67 in 4 generations; 11 diabetic subjects) showed no linkage between the size of DNA inserts and diabetes (Lod score = -5.7), suggesting a separate diabetogenic locus (or loci) in this family.This publication has 9 references indexed in Scilit:
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