Training Chicks on a Passive Avoidance Task Modulates Glutamate‐stimulated Inositol Phosphate Accumulation
- 1 January 1993
- journal article
- Published by Wiley in European Journal of Neuroscience
- Vol. 5 (1), 43-48
- https://doi.org/10.1111/j.1460-9568.1993.tb00203.x
Abstract
The effects of glutamate, N-methyl-D-aspartate (NMDA), (+)-5-methyl-10,11-dihydro-5H-dibenzo-(a,d)-cyclo-hepten 5,10-imine maleate (MK801), alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and quisqualate on the accumulation of inositol phosphates (IP) from the breakdown of phosphoinositides in vitro have been studied in tissue prisms derived from a region of the chick forebrain, the intermediate medial hyperstriatum ventrale (IMHV). In prisms from the left IMHV, glutamate stimulated IP accumulation by 10-20%, AMPA by 55% and quisqualate by 650%. These effects were more marked in the right IMHV, where AMPA stimulated IP accumulation by 157% and quisqualate by 920%. MK801 and NMDA had no significant effect on IP accumulation in either hemisphere. The left IMHV is known to be the site of a biochemical cascade resulting in synaptic remodelling following training day-old chicks on a one-trial passive avoidance task. The effect of such training was to reduce glutamate-stimulated accumulation of IP by 27% (P < 0.05) in prisms taken 30 min after training. There was no effect on prisms taken at 5 or 180 min after training, and no effect at any time in the right IMHV. MK801, injected intraperitoneally before training at a concentration known to produce amnesia for the passive avoidance task, abolished the training-induced decrease without itself affecting IP accumulation. Taken in conjunction with pharmacological and autoradiographic evidence, these results indicate that memory formation for the passive avoidance task involves the activation of NMDA receptor channels, but not quisqualate or AMPA receptors, in the left IMHV of the chick 30 min after training.Keywords
This publication has 34 references indexed in Scilit:
- Dissociation of brain sites necessary for registration and storage of memory for a one-trial passive avoidance task in the chick.Behavioral Neuroscience, 1991
- Synaptic transmission and recognition memory: Time course of changes in N-methyl-D-aspartate receptors after imprinting.Behavioral Neuroscience, 1991
- Autoradiographic distribution of binding sites for the non-NMDA receptor antagonist CNQX in chick brainNeuroscience Letters, 1990
- Glycoprotein synthesis and postsynaptic remodelling in long-term memoryNeurochemistry International, 1989
- Localization and Quantitative Autoradiography of Glutamatergic Ligand Binding Sites in Chick BrainEuropean Journal of Neuroscience, 1989
- Phosphorylation of Synaptic Proteins in Chick Forebrain: Changes with Development and Passive Avoidance TrainingJournal of Neurochemistry, 1988
- Passive avoidance training results in lasting changes in deoxyglucose metabolism in left hemisphere regions of chick brainBehavioral and Neural Biology, 1985
- Inositol Phospholipid Hydrolysis in Rat Cerebral Cortical Slices: I. Receptor CharacterisationJournal of Neurochemistry, 1984
- Psychobiology of memory: Towards a model of memory formationBiobehavioral Reviews, 1977
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976